Bosch releases pilot fermenter

Bosch releases pilot fermenter
New fermenter system can process batch sizes ranging from eight to 50 litres

Bosch has launched its new pilot fermenter for the cultivation of active pharmaceutical ingredients (API) on a laboratory and pilot scale.

Dr John Media, sales director at Bosch subsidiary Pharmatec says, “In the pharmaceutical industry, the manufacture of complex compounds using biotechnological methods continues to grow in importance. Whether the desired substance is an insulin preparation or a medication for targeted cancer therapy - our bioprocessing systems deliver optimum product quality and excellent process results. With the new pilot fermenter, Bosch has rolled out a modular, fully automatic system that is suitable for R&D applications, clinical studies in the lab, and industrial production of small batches."

Medina says the bioreactor is well suited to various cultivation processes and cell cultures, “Interchangeable mixing and dosing technologies ensure that the optimal fermentation process can be found to match the customers' needs.”

Depending on the selected mixer, the fermenter can process batch sizes from eight or 13 litres up to 50 litres. In addition, reactor sizes for 100 and 200 litres are available for pilot and small industrial batches. Bosch has complemented its existing portfolio of fermentation devices, which had previously offered production volumes ranging from 500 to 5,000 litres.

Depending on requirements, the system can be equipped with one of several interchangeable mixing elements, designed for different cell types and process controls. The mixer regulates the inflow of liquids or gases needed for cell cultivation. Sensitive cells require the use of gentler technologies like the air lift module, while more robust cells can be stirred mechanically.

The pilot fermenter is equipped with a gentle rotary pump and a second reactor vessel, it supports batch and fed-batch processes, as well as perfusion and continuous processing. Whereas the cell culture is essentially left to itself in batch processes, fed-batch processes continue to supply nutrient solutions during fermentation, resulting in higher cell density and product yield. In turn, perfusion is suited for the highest possible cell density: the fermenter is continuously supplied with fresh media, and equal amounts of waste media are extracted from the cultivation process by the system's two hollow fibre modules.

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